SKAN Research Trust and Quadram Institute Bioscience to Develop Novel Microbial Therapies

07.08.2025 - 18:03:25 | prnewswire.co.uk

SKAN Research Trust United Kingdom England United States of America India

is a UK national science capability, and its mission is to deliver healthier lives through innovation in gut health, microbiology and food and its vision is focused on understanding how food and microbes interact to promote health and prevent disease. Interconnected research themes at the Quadram Institute on the Norwich Research Park, UK, deliver a pipeline of research in plants, microbiology, food, and health: microbes and food safety; the gut microbiome; and food innovation.

About TraDIS-Xpress

TraDIS-Xpress (transposon-directed insertion-site sequencing) is a high-resolution whole-genome assay that identifies which genes are likely to affect bacterial fitness in any given condition. This uses extremely dense, highly saturated mutant libraries to identify fitness differences at base pair resolution.

TraDIS-Xpress improves upon conventional transposon mutagenesis approaches through the use of outward-facing promoters. This allows the investigation of how gene expression, as well as gene deletion, affects bacterial fitness under a given growth condition. Additionally, it allows the investigation of essential genes that cannot be inactivated and therefore cannot be assayed by other approaches.

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